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Article

Characterisation of the human GFRalpha-3 locus and investigation of the gene in Hirschsprung disease.

Journal of medical genetics - 1 Sept 2000

Onochie C I, Korngut L M, Vanhorne J B, Myers S M, Michaud D, Mulligan L M

Abstract excerpt

BACKGROUND: The GDNF family receptor alpha (GFRalpha) proteins are extracellular cell surface bound molecules that act as adapters in binding of the GDNF family of soluble neurotrophic factors to the RET receptor. These molecules are essential for development of many neural crest derived cell types and the kidney. Mutations in RET and in two members of the GDNF ligand family are associated with Hirschsprung...

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Share to Glial Cell Line-Derived Neurotrophic Factor Receptors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Membrane Glycoproteins

Share to Mutagenesis, Insertional

Share to Polymorphism, Single-Stranded Conformational

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Share to Receptors, Nerve Growth Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 10978357
DOI: 10.1136/jmg.37.9.674
PMCID: PMC1734691

Genes

GDNF
RET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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