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Article

A human ALDH1A2 gene variant is associated with increased newborn kidney size and serum retinoic acid.

Kidney international - 1 Jul 2010

El Kares Reyhan, Manolescu Daniel C, Lakhal-Chaieb Lajmi, Montpetit Alexandre, Zhang Zhao, Bhat Pangala V, Goodyer Paul

Abstract excerpt

Nephron number varies widely between 0.3 and 1.3 million per kidney in humans. During fetal life, the rate of nephrogenesis is influenced by local retinoic acid (RA) level such that even moderate maternal vitamin A deficiency limits the final nephron number in rodents. Inactivation of genes in th...

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Identifiers

PMID: 20375987
DOI: 10.1038/ki.2010.101

Genes

RET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20375987-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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