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Molecular variability of FLT3/ITD mutants and their impact on the differentiation program of 32D cells: implications for the biological properties of AML blasts.

Leukemia research - 1 Oct 2009

Pekova Sona, Ivanek Robert, Dvorak Michal, Rueggeberg Sabrina, Leicht Stefan, Li Xinping, Franz Thomas, Kozak Tomas, Vrba Jiri, Koza Vladimir, Karas Michal, Schwarz Jiri, Cetkovsky Petr, Prucha Miroslav

Abstract excerpt

FLT3 is the most frequently mutated gene in acute myeloid leukemia (AML), with internal tandem duplications (ITDs) accounting for up to 30% of its mutations. To analyze the impact of individual ITDs on the expression profile of immature myeloid cells, we have established 32D cell lines expressing nine different FLT3/ITDs isolated from AML patients and subjected them to whole genome expression profiling and...

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Identifiers

PMID: 19181379
DOI: 10.1016/j.leukres.2009.01.004

Genes

FLT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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