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Mutation spectrum of FLT3 and significance of non-canonical FLT3 mutations in haematological malignancy.

British journal of haematology - 1 Aug 2023

Ge Shuai-Shuai, Qiu Qiao-Cheng, Dai Hai-Ping, Shen Xiang-Dong, Wu Tian-Mei, Du Jia-Hui, Wan Chao-Ling, Shen Hong-Jie, Wu De-Pei, Xue Sheng-Li, Liu Song-Bai

Abstract excerpt

Fms-like tyrosine kinase 3 (FLT3) is frequently mutated in haematological malignancies. Although canonical FLT3 mutations including internal tandem duplications (ITDs) and tyrosine kinase domains (TKDs) have been extensively studied, little is known about the clinical significance of non-canonical FLT3 mutations. Here, we first profiled the spectrum of FLT3 mutations in 869 consecutively newly diagnosed acute...

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PMID: 37246158
DOI: 10.1111/bjh.18877

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