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Article

Functions of flt3 in zebrafish hematopoiesis and its relevance to human acute myeloid leukemia

4 Mar 2014

Abstract excerpt

FMS-like tyrosine kinase 3 (FLT3) is expressed in human hematopoietic stem and progenitor cells (HSPCs) but its role during embryogenesis is unclear. In acute myeloid leukemia (AML), internal tandem duplication (ITD) of FLT3 at the juxtamembrane (JMD) and tyrosine kinase (TKD) domains (FLT3-ITD(+)) occurs in 30% of patients and is associated with inferior clinical prognosis. TKD mutations (FLT3-TKD(+)) occur in...

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PMID: 24591202
DOI: 10.1182/blood-2013-02-486688

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