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Article

Targeted inhibition of FLT3 overcomes the block to myeloid differentiation in 32Dcl3 cells caused by expression of FLT3/ITD mutations.

Blood - 1 Dec 2002

Zheng Rui, Friedman Alan D, Small Donald

Abstract excerpt

Internal tandem duplication (ITD) mutations of the juxtamembrane domain-coding sequence of the FLT3 gene are found in up to 34% of patients with acute myeloid leukemia (AML) and are associated with a poor prognosis. FLT3/ITDs result in constitutive activation of the tyrosine kinase domain and transform growth factor-dependent cell lines. FLT3 activation leads to antiapoptotic and proliferative signals, but little...

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Source

Identifiers

PMID: 12393674
DOI: 10.1182/blood-2002-03-0936

Genes

FLT3
MPO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Targeted inhibition of FLT3 overcomes the block to myeloid differentiation in 32Dcl3 cells caused by expression of FLT3/ITD mutations.PMID 12393674Read ↗

Internal tandem duplication mutation of FLT3 blocks myeloid differentiation through suppression of C/EBPalpha expression.Semantic proximity Read ↗

Mutant FLT3 signaling contributes to a block in myeloid differentiationSemantic proximity Read ↗

Pediatric AML primary samples with FLT3/ITD mutations are preferentially killed by FLT3 inhibition.Semantic proximity Read ↗

Molecular variability of FLT3/ITD mutants and their impact on the differentiation program of 32D cells: implications for the biological properties of AML blasts.Semantic proximity Read ↗

Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways.Semantic proximity Read ↗

Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathwaysSemantic proximity Read ↗

Leukemia-associated activating mutation of Flt3 expands dendritic cells and alters T cell responses.Semantic proximity Read ↗

FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model.Semantic proximity Read ↗

Terminal myeloid differentiation in vivo is induced by FLT3 inhibition in FLT3/ITD AMLSemantic proximity Read ↗

Knock-in of an internal tandem duplication mutation into murine FLT3 confers myeloproliferative disease in a mouse model.Semantic proximity Read ↗

Molecular characterization and expression analysis of leucine-rich α2-glycoprotein, a novel marker of granulocytic differentiationSemantic proximity Read ↗

FLT3/ITD expression increases expansion, survival and entry into cell cycle of human haematopoietic stem/progenitor cellsSemantic proximity Read ↗

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