Article
Replication of the association between the C8orf13-BLK region and systemic lupus erythematosus in a Japanese population.
Arthritis and rheumatism - 1 Feb 2009
Ito Ikue, Kawasaki Aya, Ito Satoshi, Hayashi Taichi, Goto Daisuke, Matsumoto Isao, Tsutsumi Akito, Hom Geoffrey, Graham Robert R, Takasaki Yoshinari, Hashimoto Hiroshi, Ohashi Jun, Behrens Timothy W, Sumida Takayuki, Tsuchiya Naoyuki
Abstract excerpt
OBJECTIVE: Recent genome-wide association studies identified an association between single-nucleotide polymorphisms (SNPs) in the C8orf13 region of BLK, the B lymphoid tyrosine kinase gene, with systemic lupus erythematosus (SLE) in Caucasians. The purpose of this study was to evaluate the significance of this region in the genetic background of Japanese patients with SLE. METHODS: Fourteen tag SNPs in the...
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