C8orf13-BLK is a genetic risk locus for systemic sclerosis and has additive effects with BANK1: results from a large french cohort and meta-analysis.

doi:10.1002/art.30379

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Article

C8orf13-BLK is a genetic risk locus for systemic sclerosis and has additive effects with BANK1: results from a large french cohort and meta-analysis.

Arthritis and rheumatism - 1 Jul 2011

Coustet Baptiste, Dieudé Philippe, Guedj Mickael, Bouaziz Mathieu, Avouac Jerome, Ruiz Barbara, Hachulla Eric, Diot Elisabeth, Cracowski Jean-Luc, Tiev Kiet, Sibilia Jean, Mouthon Luc, Frances Camille, Amoura Zahir, Carpentier Patrick, Cosnes Anne, Meyer Olivier, Kahan Andre, Boileau Catherine, Chiocchia Gilles, Allanore Yannick

Abstract excerpt

OBJECTIVE: Accumulating evidence suggests that B cells are involved in systemic sclerosis (SSc). BANK1 has been reproducibly reported to be associated with diffuse cutaneous SSc (dcSSc). BLK encodes another B cell signal transducer, and a functional variant at the C8orf13-BLK locus has been found to be associated with SSc in Caucasians. However, no independent replication has been reported, and there are...

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PMID: 21480188
DOI: 10.1002/art.30379

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C8orf13-BLK is a genetic risk locus for systemic sclerosis and has additive effects with BANK1: results from a large french cohort and meta-analysis.PMID 21480188Read ↗

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