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Article

Association of BLK (rs13277113, rs2248932) polymorphism with systemic lupus erythematosus: a meta-analysis.

Molecular biology reports - 1 Oct 2011

Fan Ye, Tao Jin-Hui, Zhang Li-Ping, Li Lian-Hong, Ye Dong-Qing

Abstract excerpt

The B-cell lymphocyte kinase (BLK) is a src-family protein tyrosine kinase specifically expressed in B-lineage cells that has been implicated in the pathogenesis of systemic lupus erythematosus (SLE) and has been investigated in numerous ethnically diverse studies. However, genetic association studies that have examined the association between BLK gene variants and SLE have produced conflicting results. To shed...

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Source

Identifiers

PMID: 21152986
DOI: 10.1007/s11033-010-0573-5

Genes

BLK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Association of BLK (rs13277113, rs2248932) polymorphism with systemic lupus erythematosus: a meta-analysis.PMID 21152986Read ↗

Association between BLK polymorphisms and susceptibility to SLE : A meta-analysis.Semantic proximity Read ↗

B-cell lymphocyte kinase polymorphisms rs13277113, rs2736340, and rs4840568 and risk of autoimmune diseases: A meta-analysis.Semantic proximity Read ↗

Replication of the association between the C8orf13-BLK region and systemic lupus erythematosus in a Japanese population.Semantic proximity Read ↗

BLK pathway-associated rs13277113 GA genotype is more frequent in SLE patients and associated with low gene expression and increased flares.Semantic proximity Read ↗

Association of the C8orf13-BLK region with systemic sclerosis in North-American and European populations.Semantic proximity Read ↗

Polymorphisms of BLK are associated with renal disorder in patients with systemic lupus erythematosus.Semantic proximity Read ↗

The association of the BLK gene with SLE was replicated in Chinese Han.Semantic proximity Read ↗

Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.Semantic proximity Read ↗

Association of BLK and BANK1 gene polymorphisms with systemic lupus erythematous in Egyptian patients.Semantic proximity Read ↗

C8orf13-BLK is a genetic risk locus for systemic sclerosis and has additive effects with BANK1: results from a large french cohort and meta-analysis.Semantic proximity Read ↗

MTHFR polymorphisms (rs1801133) and systemic lupus erythematosus risk: A meta-analysis.Semantic proximity Read ↗

Interaction analysis between BLK rs13277113 polymorphism and BANK1 rs3733197 polymorphism, MMEL1/TNFRSF14 rs3890745 polymorphism in determining susceptibility to rheumatoid arthritis.Semantic proximity Read ↗

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