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Article

Molecular basis of CD4 repression by the Swi/Snf-like BAF chromatin remodeling complex.

European journal of immunology - 1 Feb 2009

Wan Mimi, Zhang Jianmin, Lai Dazhi, Jani Anant, Prestone-Hurlburt Paula, Zhao Lulu, Ramachandran Aruna, Schnitzler Gavin R, Chi Tian

Abstract excerpt

The Brg1/Brm-associated factor (BAF) chromatin remodeling complex directly binds the CD4 silencer and is essential for CD4 repression during T-cell development, because deletion of the ATPase subunit Brg1 or a dominant negative mutant of BAF57 each impairs CD4 repression in early thymocytes. Para...

Topics

Animals
CD4 Antigens
Chromatin
Chromatin Assembly and Disassembly
Chromosomal Proteins, Non-Histone
Core Binding Factor Alpha 2 Subunit
Gene Expression Regulation
Histones
Mice
Mice, Knockout
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Silencer Elements, Transcriptional

Transcription Factors

Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 19180471
DOI: 10.1002/eji.200838909
PMCID: PMC2774848

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-19180471-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Molecular basis of CD4 repression by the Swi/Snf-like BAF chromatin remodeling complex.PMID 19180471Read ↗

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