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Repressive LTR Nucleosome Positioning by the BAF Complex Is Required for HIV Latency

29 Nov 2011

Abstract excerpt

Persistence of a reservoir of latently infected memory T cells provides a barrier to HIV eradication in treated patients. Several reports have implicated the involvement of SWI/SNF chromatin remodeling complexes in restricting early steps in HIV infection, in coupling the processes of integration and remodeling, and in promoter/LTR transcription activation and repression. However, the mechanism behind the...

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PMID: 22140357
DOI: 10.1371/journal.pbio.1001206

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