Article
Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes.
Nature - 11 Jul 2002
Chi Tian H, Wan Mimi, Zhao Keji, Taniuchi Ichiro, Chen Lei, Littman Dan R, Crabtree Gerald R
Abstract excerpt
Thymic development produces two sub-lineages of T cells expressing either CD4 or CD8 co-receptors that assist antibody production and mediate cell killing, respectively. The mechanisms for mutually exclusive co-receptor expression remain poorly defined. We find that mutations in the high mobility group (HMG) domain of BAF57--a DNA-binding subunit of the mammalian SWI/SNF-like chromatin-remodelling BAF...
Topics
- Animals
- CD4 Antigens
- CD8 Antigens
- Chromatin
- Cross-Linking Reagents
- DNA Helicases
- DNA-Binding Proteins
- Flow Cytometry
- Gene Expression Regulation
- Gene Silencing
- Macromolecular Substances