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Article

Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes.

Nature - 11 Jul 2002

Chi Tian H, Wan Mimi, Zhao Keji, Taniuchi Ichiro, Chen Lei, Littman Dan R, Crabtree Gerald R

Abstract excerpt

Thymic development produces two sub-lineages of T cells expressing either CD4 or CD8 co-receptors that assist antibody production and mediate cell killing, respectively. The mechanisms for mutually exclusive co-receptor expression remain poorly defined. We find that mutations in the high mobility group (HMG) domain of BAF57--a DNA-binding subunit of the mammalian SWI/SNF-like chromatin-remodelling BAF...

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PMID: 12110891
DOI: 10.1038/nature00876

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