Article
The COP9 signalosome is required for light-dependent timeless degradation and Drosophila clock resetting.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 28 Jan 2009
Knowles Alyson, Koh Kyunghee, Wu June-Tai, Chien Cheng-Ting, Chamovitz Daniel A, Blau Justin
Abstract excerpt
The ubiquitin-proteasome system plays a major role in the rhythmic accumulation and turnover of molecular clock components. In turn, these approximately 24 h molecular rhythms drive circadian rhythms of behavior and physiology. In Drosophila, the ubiquitin-proteasome system also plays a critical role in light-dependent degradation of the clock protein Timeless (TIM), a key step in the entrainment of the molecular...
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