Article
JETLAG resets the Drosophila circadian clock by promoting light-induced degradation of TIMELESS.
Science (New York, N.Y.) - 23 Jun 2006
Koh Kyunghee, Zheng Xiangzhong, Sehgal Amita
Abstract excerpt
Organisms ranging from bacteria to humans synchronize their internal clocks to daily cycles of light and dark. Photic entrainment of the Drosophila clock is mediated by proteasomal degradation of the clock protein TIMELESS (TIM). We have identified mutations in jetlag-a gene coding for an F-box protein with leucine-rich repeats-that result in reduced light sensitivity of the circadian clock. Mutant flies show...
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