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Article

Apixaban Downregulates Endothelial Inflammatory and Prothrombotic Phenotype in an In Vitro Model of Endothelial Dysfunction in Uremia.

Cardiovascular drugs and therapy - 1 Jun 2021

Torramade-Moix Sergi, Palomo Marta, Vera Manel, Jerez Didac, Moreno-Castaño Ana Belen, Zafar M Urooj, Rovira Jordi, Diekmann Fritz, Garcia-Pagan Joan Carles, Escolar Gines, Cases Aleix, Diaz-Ricart Maribel

Abstract excerpt

PURPOSE: Chronic kidney disease (CKD) associates with inflammatory and prothrombotic phenotypes, resulting in higher cardiovascular risk. Factor Xa displays functions beyond coagulation, exhibiting proinflammatory effects. The aim of the present study was to investigate whether a direct FXa inhibitor protects from the endothelial dysfunction (ED) caused by uremia. METHODS: Macro (HUVEC) and microvascular (HMEC)...

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Identifiers

PMID: 32651897
DOI: 10.1007/s10557-020-07010-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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