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Article

Activated Protein C Ameliorates Renal Ischemia-Reperfusion Injury by Restricting Y-Box Binding Protein-1 Ubiquitination.

Journal of the American Society of Nephrology : JASN - 1 Nov 2015

Dong Wei, Wang Hongjie, Shahzad Khurrum, Bock Fabian, Al-Dabet Moh'd Mohanad, Ranjan Satish, Wolter Juliane, Kohli Shrey, Hoffmann Juliane, Dhople Vishnu Mukund, Zhu Cheng, Lindquist Jonathan A, Esmon Charles T, Gröne Elisabeth, Gröne Herman-Josef, Madhusudhan Thati, Mertens Peter R, Schlüter Dirk, Isermann Berend

Abstract excerpt

Ischemia-reperfusion injury (IRI) is the leading cause of ARF. A pathophysiologic role of the coagulation system in renal IRI has been established, but the functional relevance of thrombomodulin (TM)-dependent activated protein C (aPC) generation and the intracellular targets of aPC remain undefined. Here, we investigated the role of TM-dependent aPC generation and therapeutic aPC application in a murine renal...

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Identifiers

PMID: 26015455
DOI: 10.1681/ASN.2014080846
PMCID: PMC4625674

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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