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Article

Presenilin 1 affects focal adhesion site formation and cell force generation via c-Src transcriptional and posttranslational regulation.

The Journal of biological chemistry - 10 Apr 2009

Waschbüsch Dieter, Born Simone, Niediek Verena, Kirchgessner Norbert, Tamboli Irfan Y, Walter Jochen, Merkel Rudolf, Hoffmann Bernd

Abstract excerpt

Presenilin 1 and 2 (PS) are critical components of the gamma-secretase complex that cleaves type I transmembrane proteins within their transmembrane domains. This process leads to release of proteolytically processed products from cellular membranes and plays an essential role in signal transduction or vital functions as cell adhesion. Here we studied the function of presenilins in cell-matrix interaction of...

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Source

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Identifiers

PMID: 19176482
DOI: 10.1074/jbc.M806825200
PMCID: PMC2665068

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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