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Article

Secrets of a secretase: N-cadherin proteolysis regulates CBP function.

Cell - 5 Sept 2003

Rao Vikram R, Finkbeiner Steven

Abstract excerpt

Presenilin (PS-1) is part of the protease gamma-secretase that cleaves the membrane proteins APP and Notch. In this issue of Cell, Marambaud et al. report that PS-1 cleaves the cell adhesion molecule N-cadherin, releasing a C-terminal fragment that promotes degradation of the transcriptional coac...

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Topics

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Share to Cadherins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Enzymologic

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Source

Identifiers

PMID: 13678577
DOI: 10.1016/s0092-8674(03)00686-x

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-13678577-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Semantic proximity does not establish scientific evidence.

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Secrets of a secretase: N-cadherin proteolysis regulates CBP function.PMID 13678577Read ↗

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