Article
A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations.
Cell - 5 Sept 2003
Marambaud Philippe, Wen Paul H, Dutt Anindita, Shioi Junichi, Takashima Akihiko, Siman Robert, Robakis Nikolaos K
Abstract excerpt
Presenilin1 (PS1), a protein implicated in Alzheimer's disease (AD), forms complexes with N-cadherin, a transmembrane protein with important neuronal and synaptic functions. Here, we show that a PS1-dependent gamma-secretase protease activity promotes an epsilon-like cleavage of N-cadherin to produce its intracellular domain peptide, N-Cad/CTF2. NMDA receptor agonists stimulate N-Cad/CTF2 production suggesting...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.