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Article

Presenilin 1 is involved in maturation and trafficking of N-cadherin to the plasma membrane.

Journal of neuroscience research - 15 Oct 2003

Uemura Kengo, Kitagawa Naoyuki, Kohno Ryuichi, Kuzuya Akira, Kageyama Takashi, Chonabayashi Kazuhisa, Shibasaki Hiroshi, Shimohama Shun

Abstract excerpt

One pathological characteristic of Alzheimer's disease (AD) is extensive synapse loss. Presenilin 1 (PS1) is linked to the pathogenesis of early onset familial Alzheimer's disease (FAD) and is localized at the synapse, where it binds N-cadherin and modulates its adhesive activity. To elucidate th...

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Identifiers

PMID: 14515347
DOI: 10.1002/jnr.10753

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14515347-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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