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Article

Ectodomain shedding of SHPS-1 and its role in regulation of cell migration.

The Journal of biological chemistry - 2 Jul 2004

Ohnishi Hiroshi, Kobayashi Hisae, Okazawa Hideki, Ohe Yoshihide, Tomizawa Kyoko, Sato Ryuji, Matozaki Takashi

Abstract excerpt

SHPS-1 is a transmembrane protein whose cytoplasmic region undergoes tyrosine phosphorylation and then binds the protein-tyrosine phosphatase SHP-2. Formation of the SHPS-1-SHP-2 complex is implicated in regulation of cell migration. In addition, SHPS-1 and its ligand CD47 constitute an intercell...

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Source

Identifiers

PMID: 15123722
DOI: 10.1074/jbc.M313085200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15123722-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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