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Article

ICOS-gene variants are not associated with atopic disease susceptibility in European children.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology - 1 May 2009

Beier Katja C, Humberdros Steffi, Witt Heiko, Illi Sabina, Rüschendorf Franz, Nickel Renate, Lee Young-Ae, Lau Susanne, Wahn Ulrich, Hamelmann Eckard

Abstract excerpt

The inducible co-stimulatory molecule, ICOS, is an important regulator of T cell differentiation and effector function. Previously, it was reported that two variants in the ICOS promotor region, g.1-1413G>A and g.1-693G>A, were associated with sensitization to airborne allergens, elevated serum IgE levels and Th2 cytokine production in a Hutterite population. The aim of this study was to evaluate these two and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Promoter Regions, Genetic

Source

Identifiers

PMID: 19175887
DOI: 10.1111/j.1399-3038.2008.00777.x

Genes

ICOS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ICOS-gene variants are not associated with atopic disease susceptibility in European children.PMID 19175887Read ↗

Cutting edge: polymorphisms in the ICOS promoter region are associated with allergic sensitization and Th2 cytokine production.Semantic proximity Read ↗

STAT3 single-nucleotide polymorphisms and STAT3 mutations associated with hyper-IgE syndrome are not responsible for increased serum IgE serum levels in asthma families.Semantic proximity Read ↗

Genetic polymorphism of the human ICOS gene.Semantic proximity Read ↗

The shared CTLA4-ICOS risk locus in celiac disease, IgA deficiency and common variable immunodeficiency.Semantic proximity Read ↗

IL13 variants are associated with total serum IgE and early sensitization to food allergens in children with atopic dermatitis.Semantic proximity Read ↗

ICOS gene polymorphisms in B-cell chronic lymphocytic leukemia in the Polish population.Semantic proximity Read ↗

Allelic variation of the inducible costimulator (ICOS) gene: detection of polymorphisms, analysis of the promoter region, and extended haplotype estimation.Semantic proximity Read ↗

Genetic variation in ICOS regulates mRNA levels of ICOS and splicing isoforms of CTLA4.Semantic proximity Read ↗

ICAM1 amino-acid variant K469E is associated with paediatric bronchial asthma and elevated sICAM1 levels.Semantic proximity Read ↗

Lack of association of TIM3 polymorphisms and allergic phenotypes.Semantic proximity Read ↗

IL15 gene variants are not associated with asthma and atopy.Semantic proximity Read ↗

DNA sequence variants in epithelium-specific ETS-2 and ETS-3 are not associated with asthma.Semantic proximity Read ↗

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