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Article

Cutting edge: polymorphisms in the ICOS promoter region are associated with allergic sensitization and Th2 cytokine production.

Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 2005

Shilling Rebecca A, Pinto Jayant M, Decker Donna C, Schneider Daniel H, Bandukwala Hozefa S, Schneider Jeffrey R, Camoretti-Mercado Blanca, Ober Carole, Sperling Anne I

Abstract excerpt

The establishment of ICOS as an important regulator of Th2 development and effector function makes the ICOS locus an attractive candidate for Th2-mediated diseases, such as asthma and allergy. In evaluation of this candidate locus in humans, we identified 11 variants and determined that two in the putative promoter region are significantly associated with allergic sensitization and serum IgE levels. In addition,...

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Source

Identifiers

PMID: 16081771
DOI: 10.4049/jimmunol.175.4.2061

Genes

ICOS
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Cutting edge: polymorphisms in the ICOS promoter region are associated with allergic sensitization and Th2 cytokine production.PMID 16081771Read ↗

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An allergy-associated polymorphism in a novel regulatory element enhances IL13 expression.Semantic proximity Read ↗

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Genetic polymorphism of the human ICOS gene.Semantic proximity Read ↗

ICOS gene polymorphisms in systemic lupus erythematosus: A case-control study.Semantic proximity Read ↗

Allelic variation of the inducible costimulator (ICOS) gene: detection of polymorphisms, analysis of the promoter region, and extended haplotype estimation.Semantic proximity Read ↗

ICOS gene polymorphisms in B-cell chronic lymphocytic leukemia in the Polish population.Semantic proximity Read ↗

The shared CTLA4-ICOS risk locus in celiac disease, IgA deficiency and common variable immunodeficiency.Semantic proximity Read ↗

Th2 cell-selective enhancement of human IL13 transcription by IL13-1112C>T, a polymorphism associated with allergic inflammation.Semantic proximity Read ↗

Single nucleotide polymorphisms in the promoter regions of Foxp3 and ICOSLG genes are associated with Alopecia areata.Semantic proximity Read ↗

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