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Article

ICAM1 amino-acid variant K469E is associated with paediatric bronchial asthma and elevated sICAM1 levels.

Genes and immunity - 1 Jun 2006

Puthothu B, Krueger M, Bernhardt M, Heinzmann A

Abstract excerpt

Intercellular adhesion molecule-1 (ICAM1) acts as ligand for beta2-integrin molecules and mediates leucocyte trafficking to the site of inflammation. Intercellular adhesion molecule-1-deficient mice show impaired lymphocyte recruitment to the lung, less airway hyper-responsiveness and less lung inflammation than healthy controls. Thus, the aim of the study was to test common ICAM1 polymorphisms for association...

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Identifiers

PMID: 16625213
DOI: 10.1038/sj.gene.6364302

Genes

ICAM1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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ICAM1 amino-acid variant K469E is associated with paediatric bronchial asthma and elevated sICAM1 levels.PMID 16625213Read ↗

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