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Article

ICAM1 amino-acid variant K469E is associated with paediatric bronchial asthma and elevated sICAM1 levels.

Genes and immunity - 1 Jun 2006

Puthothu B, Krueger M, Bernhardt M, Heinzmann A

Abstract excerpt

Intercellular adhesion molecule-1 (ICAM1) acts as ligand for beta2-integrin molecules and mediates leucocyte trafficking to the site of inflammation. Intercellular adhesion molecule-1-deficient mice show impaired lymphocyte recruitment to the lung, less airway hyper-responsiveness and less lung i...

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Source

Identifiers

PMID: 16625213
DOI: 10.1038/sj.gene.6364302

Genes

ICAM1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16625213-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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ICAM1 amino-acid variant K469E is associated with paediatric bronchial asthma and elevated sICAM1 levels.PMID 16625213Read ↗

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Integrative genomic analysis identifies a role for intercellular adhesion molecule 1 in childhood asthma.Semantic proximity Read ↗

Interaction of intercellular adhesion molecule 1 (ICAM1) polymorphisms and environmental tobacco smoke on childhood asthma.Semantic proximity Read ↗

Intercellular adhesion molecule-1 and childhood asthma.Semantic proximity Read ↗

Intercellular adhesion molecule-1 K469E polymorphism: study of association with multiple sclerosis.Semantic proximity Read ↗

Intercellular adhesion molecule-1 genetic markers (+241G/A and +469A/G) in Iranian women with breast cancer.Semantic proximity Read ↗

The single nucleotide polymorphism g.1548A >G (K469E) of the ICAM-1 gene is associated with worse prognosis in non-small cell lung cancer.Semantic proximity Read ↗

Associations of a polymorphism in the intercellular adhesion molecule-1 (ICAM1) gene and ICAM1 serum levels with migraine in a Chinese Han population.Semantic proximity Read ↗

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Genetic and Biological Effects of ICAM-1 E469K Polymorphism in Diabetic Kidney Disease.Semantic proximity Read ↗

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