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Article

Small-molecule binding at an abasic site of DNA: strong binding of lumiflavin for improved recognition of thymine-related single nucleotide polymorphisms.

The journal of physical chemistry. B - 5 Feb 2009

Sankaran N B, Sato Yusuke, Sato Fuyuki, Rajendar Burki, Morita Kotaro, Seino Takehiro, Nishizawa Seiichi, Teramae Norio

Abstract excerpt

The binding behavior of lumiflavin, a biologically vital ligand, with DNA duplexes containing an abasic (AP) site and various target nucleobases opposite the AP site is studied. Lumiflavin binds selectively to thymine (T) opposite the AP site in a DNA duplex over other nucleobases. Using 1H NMR spectroscopy and fluorescence measurements, we show that ligand-DNA complexation takes place by hydrogen-bond formation...

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Identifiers

PMID: 19175344
DOI: 10.1021/jp808576t

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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