Article
Fluorescence light-up recognition of DNA nucleotide based on selective abasic site binding of an excited-state intramolecular proton transfer probe.
The Analyst - 7 Nov 2011
Xu Shujuan, Shao Yong, Ma Kun, Cui Qinghua, Liu Guiying, Wu Fei, Li Minjie
Abstract excerpt
DNA single-nucleotide polymorphism (SNP) detection has attracted much attention due to mutation-related diseases. Various fluorescence methods for SNP detection have been proposed and many are already in use. However, fluorescence enhancement for signal-on SNP identification without label modification still remains a challenge. Here, we find that the abasic site (AP site) in a DNA duplex can be developed as a...
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