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Article

SNP Discrimination by Tolane-Modified Peptide Nucleic Acids: Application for the Detection of Drug Resistance in Pathogens.

Molecules (Basel, Switzerland) - 11 Feb 2020

Takagi Kenji, Hayashi Tenko, Sawada Shinjiro, Okazaki Miku, Hori Sakiko, Ogata Katsuya, Kato Nobuo, Ebara Yasuhito, Kaihatsu Kunihiro

Abstract excerpt

During the treatment of viral or bacterial infections, it is important to evaluate any resistance to the therapeutic agents used. An amino acid substitution arising from a single base mutation in a particular gene often causes drug resistance in pathogens. Therefore, molecular tools that discriminate a single base mismatch in the target sequence are required for achieving therapeutic success. Here, we synthesized...

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Identifiers

PMID: 32053960
DOI: 10.3390/molecules25040769
PMCID: PMC7070780

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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