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Article

Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort.

The American journal of gastroenterology - 1 Mar 2009

Weersma Rinse K, Stokkers Pieter C F, Cleynen Isabelle, Wolfkamp Simone C S, Henckaerts Liesbet, Schreiber Stefan, Dijkstra Gerard, Franke Andre, Nolte Ilja M, Rutgeerts Paul, Wijmenga Cisca, Vermeire Séverine

Abstract excerpt

OBJECTIVES: Inflammatory bowel diseases (IBD)-Crohn's disease (CD) and ulcerative colitis (UC)-are chronic gastrointestinal inflammatory disorders with a complex genetic background. A genome-wide association scan by the Wellcome Trust Case Control Consortium (WTCCC) recently identified several novel susceptibility loci. METHODS: We performed a large replication study in 2,731 Dutch and Belgian IBD patients (1,656...

Topics

Autophagy-Related Proteins
Belgium
Calcium-Binding Proteins
Carrier Proteins
Colitis, Ulcerative
Crohn Disease
GTP-Binding Proteins
Gene Frequency
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genome-Wide Association Study

Genotype

Guanine Nucleotide Exchange Factors

Homeodomain Proteins

Humans

Nerve Tissue Proteins

Netherlands

Nod2 Signaling Adaptor Protein

Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 19174780
DOI: 10.1038/ajg.2008.112

Genes

CCNY
HERC2
IRGM
NELL1
PTPN2
RCC1

Provenance

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