Article
ATG16L1 and IL23R are associated with inflammatory bowel diseases but not with celiac disease in the Netherlands.
The American journal of gastroenterology - 1 Mar 2008
Weersma Rinse K, Zhernakova Alexandra, Nolte Ilja M, Lefebvre Céline, Rioux John D, Mulder Flip, van Dullemen Hendrik M, Kleibeuker Jan H, Wijmenga Cisca, Dijkstra Gerard
Abstract excerpt
BACKGROUND: Inflammatory bowel disease (IBD)--Crohn's disease (CD) and ulcerative colitis (UC)--and celiac disease are intestinal inflammatory disorders with a complex genetic background. Recently, two novel genes were found to be associated with IBD susceptibility. One, an uncommon coding variant (rs11209026) in the gene encoding for the interleukin-23 receptor (IL23R), conferred strong protection against CD....
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