Article
Pharmacogenetics and drug metabolism: an Irish perspective.
Irish journal of medical science - 1 Feb 1991
Holland P, Barry M, Feely J
Abstract excerpt
Genetic factors, particularly in relation to control of liver drug metabolism, are a major cause of variability in the response to drugs. In 145 Irish subjects 48% were fast acetylators of sulphadimidine in contrast to 80% in Chinese subjects. Eleven (7.6%) of our Irish population showed an improved ability to oxidise delrisoquine. The therapeutic implications of these findings are discussed.
Topics
- Acetylation
- Adult
- China
- Debrisoquin
- Humans
- Ireland
- Metabolism
- Oxidation-Reduction
- Phenotype
- Polymorphism, Genetic
- Sulfamethazine