Article
[Knowledge about metabolic capacity is important in drug therapy].
Lakartidningen - 5 Feb 1992
Alván G, Dahl M L
Abstract excerpt
Genetic polymorphisms are common and are also found for drug metabolising enzymes such as acetyltransferase and two distinct cytochrome P-450 isoenzymes that catalyse the oxidative metabolism of the model drugs debrisoquine and S-mephenytoin respectively. Thus, individual metabolic activity can be categorised as slow or rapid. The metabolism of a number of drugs has been shown to cosegregate with that of either...
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