Article
[Knowledge about metabolic capacity is important in drug therapy].
Lakartidningen - 5 Feb 1992
Alván G, Dahl M L
Abstract excerpt
Genetic polymorphisms are common and are also found for drug metabolising enzymes such as acetyltransferase and two distinct cytochrome P-450 isoenzymes that catalyse the oxidative metabolism of the model drugs debrisoquine and S-mephenytoin respectively. Thus, individual metabolic activity can b...
Topics
- Cytochrome P-450 Enzyme System
- Debrisoquin
- Humans
- Mephenytoin
- Pharmaceutical Preparations
- Phenotype
- Polymorphism, Genetic
