Article
pNAT and CYP2D6 gene polymorphism in epileptic patients.
Biochemical pharmacology - 1 Nov 1994
Borlak J T, Harsany V, Schneble H, Haegele K D
Abstract excerpt
Certain anticonvulsant drugs require N-acetylation as a major route of metabolic clearance. Single point mutations of the polymorphic N-acetyltransferase gene (pNAT) are the primary cause for impaired drug acetylation. Pharmacokinetic parameters are altered in slow acetylator phenotypes and this may compromise drug safety. Genetic analysis of allelic frequencies of individual pNAT genotypes point to significant...
Topics
- Acetylation
- Adolescent
- Adult
- Alleles
- Arylamine N-Acetyltransferase
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 Enzyme System
- Female
- Heterozygote
- Humans
- Male
- Mixed Function Oxygenases