Article
The genetic origin of responses to drugs.
British medical bulletin - 1 Apr 1995
Waring R H, Emery P
Abstract excerpt
Individual variation in drug metabolism has been extensively investigated. Population studies have shown that there is a wide range in metabolising ability for all detoxification pathways; the distributions may be unimodal (Gaussian) or polymodal, with subsets of individuals who differ from the majority. These may be poor metabolisers (PM) or extensive metabolisers (EM). In many cases, these phenotypes can be...
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