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The unfolded protein response during prostate cancer development

25 Jan 2009

Abstract excerpt

Accumulation of misfolded proteins in the endoplasmic reticulum (ER) induces the unfolded protein response (UPR). The UPR promotes cell survival by adjusting ER protein folding capacity but if homeostasis cannot be re-established, apoptosis is induced. The execution of life/death decisions is regulated by the three UPR branches (IRE1, PERK, ATF6) and their downstream effectors. Events that offset the balance of...

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PMID: 19172382
DOI: 10.1007/s10555-008-9180-5

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