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Energy metabolism in human renin-gene transgenic rats: does renin contribute to obesity?

Hypertension (Dallas, Tex. : 1979) - 1 Mar 2009

Gratze Petra, Boschmann Michael, Dechend Ralf, Qadri Fatimunnisa, Malchow Jeanette, Graeske Sabine, Engeli Stefan, Janke Jürgen, Springer Jochen, Contrepas Aurelie, Plehm Ralph, Klaus Susanne, Nguyen Genevieve, Luft Friedrich C, Muller Dominik N

Abstract excerpt

Renin initiates angiotensin II formation and has no other known functions. We observed that transgenic rats (TGR) overexpressing the human renin gene (hREN) developed moderate obesity with increased body fat mass and glucose intolerance compared with nontransgenic Sprague-Dawley (SD) rats. The metabolic changes were not reversed by an angiotensin-converting enzyme inhibitor, a direct renin inhibitor, or by...

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PMID: 19171793
DOI: 10.1161/HYPERTENSIONAHA.108.124966

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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