Article
Elevated blood pressure and heart rate in human renin receptor transgenic rats.
Hypertension (Dallas, Tex. : 1979) - 1 Mar 2006
Burcklé Céline A, Jan Danser A H, Müller Dominik N, Garrelds Ingrid M, Gasc Jean-Marie, Popova Elena, Plehm Ralph, Peters Jörg, Bader Michael, Nguyen Geneviève
Abstract excerpt
Recently, a receptor for renin was described that may be important for vascular uptake and activation of (pro)renin, thus leading to local generation of angiotensin II. To assess the in vivo relevance of this protein, we generated transgenic rats overexpressing the human renin receptor gene in smooth muscle tissue, under the control of a 16-kb fragment of the mouse smooth muscle myosin heavy chain gene...
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