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Article

Increased energy expenditure, dietary fat wasting, and resistance to diet-induced obesity in mice lacking renin.

Cell metabolism - 1 Dec 2007

Takahashi Nobuyuki, Li Feng, Hua Kunjie, Deng Jianbei, Wang Chih-Hong, Bowers Robert R, Bartness Timothy J, Kim Hyung-Suk, Harp Joyce B

Abstract excerpt

An overactive renin-angiotensin system is associated with obesity and the metabolic syndrome. However, the mechanisms behind it are unclear. Cleaving angiotensinogen to angiotensin I by renin is a rate-limiting step of angiotensin II production, but renin is suggested to have angiotensin-independent effects. We generated mice lacking renin (Ren1c) using embryonic stem cells from C57BL/6 mice, a strain prone to...

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Identifiers

PMID: 18054319
DOI: 10.1016/j.cmet.2007.10.011
PMCID: PMC2174204

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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