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Article

Rats Transgenic for Human Renin and Human Angiotensinogen as a Model for Gestational Hypertension

1 Nov 2000

Abstract excerpt

Animal models of gestational hypertension are problematic. A novel mouse model was described earlier. The dams in that study were transgenic for human angiotensinogen and the sires for human renin; human renin was expressed in and produced by the placenta. This model was adapted to the rat, which has greater utility in terms of chronic instrumentation and physiologic measurements. Female rats transgenic for human...

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PMID: 11053481
DOI: 10.1681/asn.v11112056

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