Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Oct-4 Is Critical for Survival/Antiapoptosis of Murine Embryonic Stem Cells Subjected to Stress: Effects Associated with Stat3/Survivin

11 Oct 2007

Abstract excerpt

Understanding survival/antiapoptosis of murine embryonic stem (ES) cells may enhance their clinical potential. We hypothesized that Oct-4 might be involved in survival of undifferentiated ES cells under stress. The Oct-4 tetracycline conditional knockout cell line ZHBtc4 was used to test this possibility, and apoptosis was induced by either etoposide, heat shock, or UV exposure. Apoptosis in Oct-4 knocked-down ES...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell death mechanisms and regulation
Share to Cytokine Signaling Pathways and Interactions
Share to Pluripotent Stem Cells Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17932422
DOI: 10.1634/stemcells.2007-0401

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Oct-4 Is Critical for Survival/Antiapoptosis of Murine Embryonic Stem Cells Subjected to Stress: Effects Associated with Stat3/SurvivinPMID 17932422Read ↗

Oct4 expression in adult stem cells: evidence in support of the stem cell theory of carcinogenesisSemantic proximity Read ↗

Cisplatin Hypersensitivity of Testicular Germ Cell Tumors Is Determined by High Constitutive Noxa Levels Mediated by Oct-4Semantic proximity Read ↗

Interplay of Oct4 with Sox2 and Sox17: a molecular switch from stem cell pluripotency to specifying a cardiac fateSemantic proximity Read ↗

HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth.Semantic proximity Read ↗

Survivin modulates genes with divergent molecular functions and regulates proliferation of hematopoietic stem cells through Evi-1.Semantic proximity Read ↗

Survivin acts as an antiapoptotic factor during the development of mouse preimplantation embryos.Semantic proximity Read ↗

Stress decreases host viral resistance and increases Covid susceptibility in embryonic stem cells.Semantic proximity Read ↗

Expression of pluripotency-associated genes in the surviving fraction of cultured human embryonic stem cells is not significantly affected by ionizing radiationSemantic proximity Read ↗

Octamer 4 Small Interfering RNA Results in Cancer Stem Cell–Like Cell ApoptosisSemantic proximity Read ↗

Mesenchymal stem cells maintain their defining stem cell characteristics after treatment with cisplatin.Semantic proximity Read ↗

Oct-4 mRNA and protein expression during human preimplantation developmentSemantic proximity Read ↗

A general mechanism for transcription regulation by Oct1 and Oct4 in response to genotoxic and oxidative stress.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.