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Article

Inducible Expression and Phosphorylation of Coactivator BOB.1/OBF.1 in T Cells

11 Jul 1997

Abstract excerpt

BOB.1/OBF.1 is a transcriptional coactivator that is constitutively expressed in B cells and interacts with the Oct1 and Oct2 transcription factors. Upon activation of Jurkat T cells and primary murine thymocytes with phorbol esters and ionomycin, BOB.1/OBF.1 expression and transactivation function were induced. BOB.1/OBF.1 was phosphorylated at Ser184 both in vivo and in vitro, and this modification was required...

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Identifiers

PMID: 9211847
DOI: 10.1126/science.277.5323.221

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Inducible Expression and Phosphorylation of Coactivator BOB.1/OBF.1 in T CellsPMID 9211847Read ↗

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The OBF-1 gene locus confers B cell-specific transcription by restricting the ubiquitous activity of its promoter.Semantic proximity Read ↗

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