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Article

Phosphorylation regulates activity of 7-dehydrocholesterol reductase (DHCR7), a terminal enzyme of cholesterol synthesis.

The Journal of steroid biochemistry and molecular biology - 1 Jan 2017

Prabhu Anika V, Luu Winnie, Sharpe Laura J, Brown Andrew J

Abstract excerpt

Cholesterol is essential for survival, but too much or too little can cause disease. Thus, cholesterol levels must be kept within close margins. 7-dehydrocholesterol reductase (DHCR7) is a terminal enzyme of cholesterol synthesis, and is essential for embryonic development. Largely, DHCR7 research is associated with the developmental disease Smith-Lemli-Opitz syndrome, which is caused by mutations in the DHCR7...

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Identifiers

PMID: 27520299
DOI: 10.1016/j.jsbmb.2016.08.003

Genes

DHCR7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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