Article
A single serine in the carboxyl terminus of cardiac essential myosin light chain-1 controls cardiomyocyte contractility in vivo.
Circulation research - 13 Mar 2009
Meder Benjamin, Laufer Christina, Hassel David, Just Steffen, Marquart Sabine, Vogel Britta, Hess Alexander, Fishman Mark C, Katus Hugo A, Rottbauer Wolfgang
Abstract excerpt
Although it is well known that mutations in the cardiac essential myosin light chain-1 (cmlc-1) gene can cause hypertrophic cardiomyopathy, the precise in vivo structural and functional roles of cMLC-1 in the heart are only poorly understood. We have isolated the zebrafish mutant lazy susan (laz), which displays severely reduced contractility of both heart chambers. By positional cloning, we identified a nonsense...
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