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Article

Depletion of zebrafish essential and regulatory myosin light chains reduces cardiac function through distinct mechanisms.

Cardiovascular research - 1 Jul 2008

Chen Zhenyue, Huang Wei, Dahme Tillman, Rottbauer Wolfgang, Ackerman Michael J, Xu Xiaolei

Abstract excerpt

AIMS: Mutations in the essential myosin light chain (ELC) and regulatory myosin light chain (RLC) genes have been linked to sarcomeric hypertrophic cardiomyopathies in humans; however, the specific functions of the different myosin light chains during cardiogenesis in a vertebrate animal are not well understood. METHODS AND RESULTS: Using zebrafish (Danio rerio) as a model organism, we have identified cmlc1 and...

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Source

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Identifiers

PMID: 18343897
DOI: 10.1093/cvr/cvn073
PMCID: PMC2724891

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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