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Distinct troponin C isoform requirements in cardiac and skeletal muscle

5 Oct 2010

Abstract excerpt

The zebrafish mutant silent partner is characterized by a dysmorphic, non-contractile ventricle resulting in an inability to generate normal blood flow. We have identified the genetic lesion in the zebrafish homolog of the slow twitch skeletal/cardiac troponin C gene. Although human troponin C1 (TNNC1) is expressed in both cardiac and skeletal muscle, duplication of this gene in zebrafish has resulted in...

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PMID: 20925115
DOI: 10.1002/dvdy.22445

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