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Article

Overexpression of microRNA-1 impairs cardiac contractile function by damaging sarcomere assembly

18 Jun 2012

Abstract excerpt

AIMS: The purpose of the present study was to evaluate the effects of overexpression of microRNA-1 (miR-1) on cardiac contractile function and the potential molecular mechanisms. METHODS AND RESULTS: Transgenic (Tg) mice (C57BL/6) for cardiac-specific overexpression of miR-1 driven by the α-myosin heavy chain promoter were generated and identified by real-time reverse-transcription polymerase chain reaction with...

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PMID: 22719074
DOI: 10.1093/cvr/cvs196

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