Article
The complex formation of MASP-3 with pattern recognition molecules of the lectin complement pathway retains MASP-3 in the circulation.
Frontiers in immunology - 1 Jan 2022
Kusakari Kohei, Machida Takeshi, Ishida Yumi, Omori Tomoko, Suzuki Toshiyuki, Sekimata Masayuki, Wada Ikuo, Fujita Teizo, Sekine Hideharu
Abstract excerpt
The complement system plays an important role in host defense and is activated via three different activation pathways. We have previously reported that mannose-binding lectin-associated serine protease (MASP)-3, unlike its splicing variant MASP-1, circulates in an active form and is essential for the activation of the alternative pathway (AP) via the activation of complement factor D (FD). On the other hand,...
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