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Article

Fast two-stage phasing of large-scale sequence data.

American journal of human genetics - 7 Oct 2021

Browning Brian L, Tian Xiaowen, Zhou Ying, Browning Sharon R

Abstract excerpt

Haplotype phasing is the estimation of haplotypes from genotype data. We present a fast, accurate, and memory-efficient haplotype phasing method that scales to large-scale SNP array and sequence data. The method uses marker windowing and composite reference haplotypes to reduce memory usage and computation time. It incorporates a progressive phasing algorithm that identifies confidently phased heterozygotes in...

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Identifiers

PMID: 34478634
DOI: 10.1016/j.ajhg.2021.08.005
PMCID: PMC8551421

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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