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Article

Chromosomal haplotypes by genetic phasing of human families.

American journal of human genetics - 9 Sept 2011

Roach Jared C, Glusman Gustavo, Hubley Robert, Montsaroff Stephen Z, Holloway Alisha K, Mauldin Denise E, Srivastava Deepak, Garg Vidu, Pollard Katherine S, Galas David J, Hood Leroy, Smit Arian F A

Abstract excerpt

Assignment of alleles to haplotypes for nearly all the variants on all chromosomes can be performed by genetic analysis of a nuclear family with three or more children. Whole-genome sequence data enable deterministic phasing of nearly all sequenced alleles by permitting assignment of recombinations to precise chromosomal positions and specific meioses. We demonstrate this process of genetic phasing on two...

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Identifiers

PMID: 21855840
DOI: 10.1016/j.ajhg.2011.07.023
PMCID: PMC3169815

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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