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Article

Genetic polymorphisms in the thioredoxin 2 (TXN2) gene and risk for spina bifida.

American journal of medical genetics. Part A - 1 Feb 2009

Wen Shu, Lu Wei, Zhu Huiping, Yang Wei, Shaw Gary M, Lammer Edward J, Islam Ana, Finnell Richard H

Abstract excerpt

TXN2 encodes human thioredoxin 2, a small redox protein important in cellular antioxidant defenses, as well as in the regulation of apoptosis. Txn2 knockout mice fail to complete neural tube closure by E10.5 and die in utero. We hypothesized that genetic variation in human TXN2 gene may alter the function of the encoded protein in a manner associated with an increased risk for neural tube defects (NTDs). A DNA...

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Identifiers

PMID: 19165900
DOI: 10.1002/ajmg.a.32589
PMCID: PMC2970524

Genes

TXN2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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