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Article

Diabetes and obesity-related genes and the risk of neural tube defects in the national birth defects prevention study.

American journal of epidemiology - 15 Dec 2012

Lupo Philip J, Canfield Mark A, Chapa Claudia, Lu Wei, Agopian A J, Mitchell Laura E, Shaw Gary M, Waller D Kim, Olshan Andrew F, Finnell Richard H, Zhu Huiping

Abstract excerpt

Few studies have evaluated genetic susceptibility related to diabetes and obesity as a risk factor for neural tube defects (NTDs). The authors investigated 23 single nucleotide polymorphisms among 9 genes (ADRB3, ENPP1, FTO, LEP, PPARG, PPARGC1A, SLC2A2, TCF7L2, and UCP2) associated with type 2 diabetes or obesity. Samples were obtained from 737 NTD case-parent triads included in the National Birth Defects...

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Source

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Identifiers

PMID: 23132673
DOI: 10.1093/aje/kws190
PMCID: PMC3571234

Genes

FTO
LEP
UCP2
ADRB3
ENPP1
PPARG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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